Modern Analytical Techniques

Shree Sai Prakashan is writing a full set of B.Pharm titles to this new NEP 2020 syllabus. Get notified the moment the book for this subject is released, or pre-book sets for your college.

Unit 1 · Nuclear Magnetic Resonance Spectroscopy 10 hrs

The principles of ¹H-NMR and ¹³C-NMR; the solvents used and sample preparation; chemical shift, spin–spin coupling and integration; instrumentation; and the interpretation of spectra in the structural elucidation of pharmaceutical molecules.

Unit 2 · Mass Spectrometry 8 hrs

Principles, fragmentation and the rules governing it; ionization techniques including electron impact, chemical ionization, MALDI, FAB and atmospheric-pressure ionization; mass analysers and detectors; and applications in pharmaceutical analysis and structure determination.

Unit 3 · X-Ray Crystallography and Thermal Analysis 10 hrs

The origin of X-rays and the basic aspects of crystals; X-ray crystallography and diffraction methods and their pharmaceutical applications; and thermal methods of analysis — their introduction, instrumentation, the factors affecting measurement and their applications.

Unit 4 · Green Analytical Chemistry and Bioanalytical Methods 12 hrs

The types of green solvents and the computational tools used to assess the greenness of analytical methods; and an introduction to bioanalytical method development — the extraction of drugs from biological matrices, and method validation for bioanalysis.

Unit 5 · Bioequivalence Studies and Biosimilars 5 hrs

The bioavailability and bioequivalence study protocol and its regulatory requirements; and an introduction to biosimilars and the analytical comparability exercise used to establish them.